Additional causes for distal sensory polyneuropathy in diabetic patients

Sensory Neuropathies Chronic Sensorimotor Distal Symmetrical Polyneuropathy

[Depressive symptoms and quality of life in type 2 diabetic patients with diabetic distal polyneuropathy].

OBJECTIVE To investigate the impact of depressive symptoms and neuropathic pain in the quality of life (QL) of diabetic patients with diabetic distal polyneuropathy (DDP). METHODS Two hundred and four patients with type 2 diabetes mellitus were evaluated. The diagnosis of DDP was achieved using the Neuropathy Disability Score and Neuropathy Symptom Score questionnaires. The severity of neurop...

Sensory Ganglion Cell Culture for the Study of Diabetic Polyneuropathy

The commonest form of diabetic neuropathy is a distal symmetric sensory polyneuropathy. Its pathological basis has been disputed. One view has been that it is the result of multifocal hypoxic lesions in nerve that summate to produce symmetric distal axonal loss, although there are substantial indications that this is only a partial explanation. The autopsied cases reported by Sugimura and Dyck,...

Proximal Neuropathic Lesions in Distal Symmetric Diabetic Polyneuropathy

OBJECTIVE This study investigated high-resolution magnetic resonance neurography (MRN) in distal symmetric diabetic polyneuropathy (dPNP). RESEARCH DESIGN AND METHODS MRN comprised high-resolution transaxial imaging of peripheral nerves of the lower limbs in 20 patients with type 2 diabetes (10 with dPNP, type 2/dPNP[+], and 10 without dPNP, type 2/dPNP[-]), seven patients with type 1 diabete...

Impaired Distal Thermoregulation in Diabetes and Diabetic Polyneuropathy

OBJECTIVE To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness and sleep. RESEARCH DESIGN AND METHODS Normal subjects, diabetic subjects without neuropathy, diabetic subjects with small-fiber diabetic polyneuropathy, and those with advanced diabetic polyneuropathy were categorized based on neurological examination, nerve conduct...